Research report
A research report is the sourced material a domain
dossier is synthesized from — generated on a plan and a cadence, one topic per file.
A report carries no confidence tags. Its bracketed markers say who might have
an incentive to shade a line; none of them says anyone checked it. To reach a score, a line has
to be drafted onto a candidate as unverified and pass the Verifier or the
Corroborator, like everything else.
Section reference-products · Version 2026-09-25 · Cadence quarterly · Evidence class 2 published · Sources 22 · Supersedes none
Domain: ctdna-mrd-assay-validation · Scope: vendor web stores and distributor catalogues (Fisher Scientific, VWR, Thomas Scientific, vendor online shops) reachable by WebSearch, WebFetch and direct HTTPS retrieval on 2026-09-25, plus PubMed via the literature connector for prices printed in methods sections. Records product name, catalogue number, VAF (variant allele frequency) levels, matrix, input mass per vial, vials per pack, and a displayed price with its retrieval date. Excludes negotiated, contract or quoted prices, anything behind a customer login, and any price not printed on a retrieved page.
Sourcing: every price rests on one distributor or vendor web-store page read on 2026-09-25, all directional; SeraCare/LGC prices are visible only through Fisher Scientific, Thermo Fisher's AcroMetrix shows two different prices on two affiliated storefronts, and Horizon/Revvity and Twist show pack formats but no price on any page retrieved
None of the three named vendors shows a price on its own web store without a login or a quote. SeraCare/LGC's pages say "Please sign in to view pricing," Horizon/Revvity's say "Select your product to view pricing," and Twist's product sheet gives catalogue numbers and a sales address but no price. Each line with a sourcing marker in section 3 rests on one page. The prices located are distributor web prices on Fisher Scientific for SeraCare/LGC products, plus Thermo Fisher's AcroMetrix ctDNA (circulating tumour DNA) plasma control, which shows one price on thermofisher.com and a different one on fishersci.com. No peer-reviewed methods section printing a reference-material price was found.
_Baseline (v1). No prior version; this establishes the starting point for future diffs._
| Product | Vendor cat. no. | Fisher cat. no. | VAF / TF | Matrix | Mass per vial × vials | Fisher price | Sources |
|---|---|---|---|---|---|---|---|
| ctDNA Complete Reference Material AF0.5% | 0710-0672 | NC1626186 | 0.5%, 25 variants | SeraCon Matribase "(human plasma-like)", 5 mL at 25 ng/mL | 125 ng × 1 | $919.82 each | [1][8] |
| ctDNA Complete Reference Material AF0.1% | 0710-0673 | NC1626188 | 0.1%, 25 variants | plasma-like, 5 mL | 125 ng × 1 | $919.82 each | [2][9] |
| ctDNA Complete Reference Material AF1% | 0710-0671 (Fisher supplier no. 07100671) | NC1626184 | 1% | 1 x 5 mL (Fisher title) | not on Fisher page | $919.82 each | [10] |
| ctDNA Complete Reference Material AF2.5% | 0710-0670 (supplier no. 07100670) | NC1626191 | 2.5% | 1 x 5 mL (Fisher title) | not on Fisher page | $919.82 each | [11] |
| ctDNA Complete Reference Material AF5% | 0710-0669 (supplier no. 07100669) | NC1654538 | 5% | 5 mL (Fisher title) | not on Fisher page | $919.82 each | [12] |
| ctDNA Complete Mutation Mix AF0.5% | 0710-0531 | NC1717818 | 0.5%, 25 variants | purified DNA in TE, 25 µL at 10 ng/µL | 250 ng × 1 | $1,350.95 each | [4][13] |
| ctDNA Complete Mutation Mix AF0.1% | 0710-0532 | none located | 0.1%, 25 variants | TE, 25 µL | 250 ng × 1 | no price located | [3] |
| ctDNA MRD (molecular residual disease) Panel Mix | 0710-2146 | NC2587386 | "0%, 0.5%, 0.05% & 0.005%" tumor levels, ">600" variants | purified DNA in TE | "4 x 200 ng" (4 vials × 20 µL) | $1,919.59 each | [5][14] |
| ctDNA Mutation Mix v2 AF0.125% | 0710-0143 | NC1814090 | 0.125%, 40 variants | TE, 25 µL | 250 ng × 1 | $1,218.70 each | [6][15] |
| ctDNA Mutation Mix v2 WT | 0710-0144 (supplier no. 07100144) | NC1894274 | 0% | 1 x 25 µL (Fisher title) | not on Fisher page | $1,218.70 each | [16] |
| ctDNA Reference Material v4 AF0.1% | 0710-3992 | none located | 0.1%, 93 variants | plasma-like, 5 mL at 25 ng/mL | 125 ng × 1 | no price located | [7] |
All Fisher prices above carry [single-source · manufacturer]. The format columns come from the vendor's own page, where one was read, and carry [manufacturer].
The Mimix Multiplex I cfDNA Reference Standard Set page lists four vials: "100% Multiplex I Wild Type cfDNA Reference Standard (Part No.: HD776)", and HD777 (5%), HD778 (1%) and HD779 (0.1%). Each vial is "Unit size: 350 ng per vial" at "Concentration: 20 ng/µl" in Tris-EDTA, with a 160 bp fragment size, covering EGFR, KRAS, NRAS and PIK3CA. No price was displayed. [17] [single-source · manufacturer]
"The Twist cfDNA Pan-Cancer Reference Standard v2 Set consists of 7 individual tubes with 300 ng per tube for each of the 7 different VAFs: 0% (WT), 0.1%, 0.25%, 0.5%, 1%, 2%, 5%. Twist also offers each individual VAF in a smaller 600ng and larger 3ug configurations." Catalogue numbers: 107576 (set, 300 ng kit), 107577–107583 (3 µg singles) and 107584–107590 (600 ng singles). The material is wild-type cell-line cfDNA plus synthetic variant oligos, research use only. No price is given. [18] [single-source · manufacturer]
The AcroMetrix Multi-Analyte ctDNA Plasma Control A–E (RUO (research use only)) comes as 13 variants at "5 variant allele frequencies". Each catalogue number is one control level: "Each kit contains 1 vial with 60 ng/mL DNA content in 2 mL plasma". [19][21] [manufacturer]
The two storefronts belong to the same company, so they are not independent sources. Neither page says why the prices differ.
[1] Seraseq ctDNA Complete Reference Material AF0.5% product page — SeraCare / LGC Clinical Diagnostics (published date not stated on page; accessed 2026-09-25). catalog no. 0710-0672 — https://www.seracare.com/Seraseq-ctDNA-Complete-Reference-Material-AF05-0710-0672/ [manufacturer] [2] Seraseq ctDNA Complete Reference Material AF0.1% product page — SeraCare / LGC Clinical Diagnostics (published date not stated on page; accessed 2026-09-25). catalog no. 0710-0673 — https://www.seracare.com/Seraseq-ctDNA-Complete-Reference-Material-AF01-0710-0673/ [manufacturer] [3] Seraseq ctDNA Complete Mutation Mix AF0.1% product page — SeraCare / LGC Clinical Diagnostics (published date not stated on page; accessed 2026-09-25). catalog no. 0710-0532 — https://www.seracare.com/Seraseq-ctDNA-Complete-Mutation-Mix-AF01-0710-0532/ [manufacturer] [4] Seraseq ctDNA Complete Mutation Mix AF0.5% product page — SeraCare / LGC Clinical Diagnostics (published date not stated on page; accessed 2026-09-25). catalog no. 0710-0531 — https://www.seracare.com/Seraseq-ctDNA-Complete-Mutation-Mix-AF05-0710-0531/ [manufacturer] [5] Seraseq ctDNA MRD Panel Mix product page — SeraCare / LGC Clinical Diagnostics (published date not stated on page; accessed 2026-09-25). catalog no. 0710-2146 — https://www.seracare.com/Seraseq-ctDNA-MRD-Panel-Mix-0710-2146/ [manufacturer] [6] Seraseq ctDNA Mutation Mix v2 AF0.125% product page — SeraCare / LGC Clinical Diagnostics (published date not stated on page; accessed 2026-09-25). catalog no. 0710-0143 — https://www.seracare.com/Seraseq-ctDNA-Mutation-Mix-v2-AF0125-0710-0143/ [manufacturer] [7] Seraseq ctDNA Reference Material v4 AF0.1% product page — SeraCare / LGC Clinical Diagnostics (published date not stated on page; accessed 2026-09-25). catalog no. 0710-3992 — https://www.seracare.com/Seraseq-ctDNA-Reference-Material-v4-AF01-0710-3992/ [manufacturer] [8] Seracare Life Sciences Inc Seraseq ctDNA Complete Reference Material AF0.5%, 1x5mL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1626186 — https://www.fishersci.com/shop/products/seraseq-reference-mat-af0-5/NC1626186 [manufacturer] [9] Seracare Life Sciences Inc Seraseq ctDNA Complete Reference Material AF0.1%, 1x5mL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1626188 — https://www.fishersci.com/shop/products/seraseq-reference-mat-af0-1/NC1626188 [manufacturer] [10] Seracare Life Sciences Inc Seraseq ctDNA Complete Reference Material AF1%, 1x5mL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1626184 — https://www.fishersci.com/shop/products/seraseq-ctdna-complete-refer/NC1626184 [manufacturer] [11] Seracare Life Sciences Inc Seraseq ctDNA Complete Reference Material AF2.5%, 1x5mL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1626191 — https://www.fishersci.com/shop/products/seraseq-reference-mat-af2-5/NC1626191 [manufacturer] [12] Seracare Life Sciences Inc Seraseq ctDNA Complete Reference Material AF5%, 5mL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1654538 — https://www.fishersci.com/shop/products/seraseq-ctdna-complete-refer-1/NC1654538 [manufacturer] [13] Seracare Life Sciences Inc Seraseq ctDNA Complete Mutation Mix AF 0.5%, 25 uL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1717818 — https://www.fishersci.com/shop/products/seraseq-ctdna-comp-mut-af-0-5-1/NC1717818 [manufacturer] [14] Seracare Life Sciences Inc SERASEQ CTDNA MRD PANEL MIX — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC2587386 — https://www.fishersci.com/shop/products/NC2587386/NC2587386 [manufacturer] [15] Seracare Life Sciences Inc ctDNA Mutation Mix v2 AF0.125%, 25 uL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1814090 — https://www.fishersci.com/shop/products/ctdna-mutation-mix-afo-13/NC1814090 [manufacturer] [16] Seracare Life Sciences Inc Seraseq ctDNA Mutation Mix v2 WT, 1 x 25 µL — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. NC1894274 — https://www.fishersci.com/shop/products/seraseq-ctdna-mutation-mix-wt/NC1894274 [manufacturer] [17] Mimix Multiplex I, cfDNA Reference Standard Set product page — Horizon Discovery / Revvity (published date not stated on page; accessed 2026-09-25). catalog nos. HD776, HD777, HD778, HD779 — https://horizondiscovery.com/en/reference-standards/products/multiplex-i-cfdna-reference-standard-set [manufacturer] [18] Twist cfDNA Pan-Cancer Reference Standard v2, product sheet DOC-001467 REV 2.0 — Twist Bioscience (published date not stated on the document; accessed 2026-09-25). catalog no. 107576 — https://www.twistbioscience.com/content/dam/twistbioscience/resources/2024-03/DOC-001467%20cfDNA%20Pan-Cancer%20Reference%20Standard%20v2%20REV2%20SINGLES.pdf [manufacturer] [19] AcroMetrix Multi-Analyte ctDNA Plasma Control A - E (RUO), Multi-Analyte ctDNA Control A — Thermo Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. 957563 — https://www.thermofisher.com/order/catalog/product/957563 [manufacturer] [20] AcroMetrix Multi-Analyte ctDNA Plasma Control A - E (RUO), Multi-Analyte ctDNA Control D — Thermo Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. 957566 — https://www.thermofisher.com/order/catalog/product/957566 [manufacturer] [21] Thermo Scientific AcroMetrix Multi-Analyte ctDNA Plasma Control A (RUO) — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. 10-095-7563 — https://www.fishersci.com/shop/products/acrometrix-multi-analyte-ctdna-plasma-control-a-e-ruo/100957563 [manufacturer] [22] Thermo Scientific AcroMetrix Multi-Analyte ctDNA Plasma Control D (RUO) — Fisher Scientific (published date not stated on page; accessed 2026-09-25). catalog no. 10-095-7566 — https://www.fishersci.com/shop/products/acrometrix-multi-analyte-ctdna-plasma-control-a-e-ruo/100957566 [manufacturer]
Well established: nothing. No price in this report rests on two independent sources. The only product priced on two storefronts, AcroMetrix, shows two different figures, and both storefronts belong to Thermo Fisher.
Thin: every line. Each Fisher price is [single-source · manufacturer]: a distributor web price on the day of retrieval, which the page itself says may differ from contract pricing and may include supplier surcharges. The SeraCare/LGC Fisher listings are marked "Non-distribution item offered as a customer accommodation", so they may not match SeraCare's own list price. SeraCare hides that list price behind a login, and it was not retrieved. The pack formats for the AF1%, AF2.5%, AF5% and v2 WT items come from Fisher's product titles only. SeraCare's own pages for those four items were not opened.
Rescoped from class 3: none. The question asks what is printed, not what anyone would pay.
Out of scope: negotiated, contract and quoted prices; prices behind the SeraCare/LGC, Horizon/Revvity, Twist and Fisher customer logins; non-US storefronts and currencies.
Not searched vs. not found:
[inference] Dividing Fisher's web price by the labelled DNA mass per pack gives roughly $7.36/ng for the 125 ng ctDNA Complete Reference Material [8][1], $5.40/ng for the 250 ng Complete Mutation Mix [13][4], $4.87/ng for the 250 ng v2 Mutation Mix [15][6], and $2.40/ng for the 4 × 200 ng MRD Panel Mix [14][5]. These are the writer's own arithmetic on single-source distributor prices, not published figures. They should not stand in for a SeraCare list price.
[inference] Idea-003 claims 48 and 49 need an incumbent list price. The closest anchor found here is a distributor web price, not a vendor list price. The Seraseq ctDNA MRD Panel Mix is the only located priced product with sub-0.1% levels (0.05% and 0.005%).
| Proposition | Evidence class | Resolvable identifier | Dossier section |
|---|---|---|---|
| On 2026-09-25 Fisher Scientific displayed $1,919.59 each for the Seraseq ctDNA MRD Panel Mix (SeraCare 0710-2146) | 2 published | catalog no. NC2587386 | 5 |
| SeraCare lists the Seraseq ctDNA MRD Panel Mix as 4 vials × 200 ng of purified DNA at tumor levels 0%, 0.5%, 0.05% and 0.005% | 2 published | catalog no. 0710-2146 | 5 |
| On 2026-09-25 Fisher Scientific displayed $919.82 each for Seraseq ctDNA Complete Reference Material AF0.1%, 1 x 5 mL | 2 published | catalog no. NC1626188 | 5 |
| SeraCare lists ctDNA Complete Reference Material AF0.1% as 125 ng in a single 5 mL vial of plasma-like matrix | 2 published | catalog no. 0710-0673 | 5 |
| On 2026-09-25 SeraCare's own store did not show a price for its ctDNA products without sign-in ("Please sign in to view pricing") | 2 published | catalog no. 0710-0672 | 5 |
| Twist's cfDNA Pan-Cancer Reference Standard v2 set is 7 tubes × 300 ng at 0%, 0.1%, 0.25%, 0.5%, 1%, 2% and 5% VAF, with no price printed on the product sheet | 2 published | catalog no. 107576 | 5 |
| Horizon's Mimix Multiplex I cfDNA set is four 350 ng vials at 0%, 0.1%, 1% and 5%, with no price displayed on the product page | 2 published | catalog nos. HD776, HD777, HD778, HD779 | 5 |
| On 2026-09-25 thermofisher.com displayed USD 490.00 each for AcroMetrix Multi-Analyte ctDNA Plasma Control A (1 vial, 2 mL plasma at 60 ng/mL) | 2 published | catalog no. 957563 | 5 |
| On 2026-09-25 fishersci.com displayed $1,617.00 per pack of 1 for the same AcroMetrix Control A | 2 published | catalog no. 10-095-7563 | 5 |
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